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Clomiphene
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When a woman's ovaries aren't working properly, clomiphene aids in promoting ovulation and pregnancy. If you have ovarian cysts, liver disease, or are pregnant, you should never take clomiphene.

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Description

A non-steroidal fertility drug is clomifene. When certain medical conditions, like polycystic ovary syndrome, prevent ovulation from occurring naturally in a woman, clomiphene is used to induce ovulation. There are additional uses for clomiphene not covered by this medication guide. It induces the release of hormones from the pituitary gland that are necessary to promote ovulation (the release of an egg from the ovary).

Dosage

Pay close attention to the instructions on your prescription label. If ovulation does not appear to occur after the first course of therapy, a second course of 100 mg daily (two 50 mg tablets given as a single daily dose) for 5 days may be prescribed. Exactly as directed by your doctor, take this medication. The recommended dose of clomiphene to induce ovulation and promote pregnancy in women with dysfunctional ovaries is 50 mg daily for 5 days per treatment. However, your doctor may recommend a different dose depending on your weight, age, other medical conditions, and other medications you are taking.

Missed dose

If you forget to take your clomiphene dose, call your doctor for directions.

Overdose

If you take too much clomiphene, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Storage

However, you shouldn't dispose of this medication in the toilet. A medicine take-back program is the preferable method for getting rid of your medication. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for toddlers to open. Keep this medication tightly closed in its original container away from the reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more information. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

Call your doctor for medical advice about side effects. Call your doctor right away if you have any of the following symptoms of OHSS: Side effects of clomiphene (more information) There are several typical side effects of clomiphene. Get emergency medical help if you have any signs of an allergic reaction to clomiphene: hives; difficult breathing; swelling of your face, lips, tongue, or throat. The symptoms of OHSS may be fatal. Some women using this medicine develop a condition called ovarian hyperstimulation syndrome (OHSS), especially after the first treatment. If you experience any of the following symptoms while taking clomiphene: There may be additional side effects; this is not a comprehensive list. You can contact the FDA to report side effects at 1-800-FDA-1088. flushing (warmth, redness, or tingly feeling); breast pain or tenderness; headache; or breakthrough bleeding or spotting. pelvic pain or pressure, enlargement in your pelvic area; vision problems; seeing flashes of light or "floaters" in your vision; increased sensitivity of your eyes to light; or heavy vaginal bleeding. If you experience chest pain, bloating, nausea, vomiting, diarrhea, rapid weight gain, especially around your face and midsection, little to no urination, a rapid heartbeat, or shortness of breath (especially when lying down), these symptoms may be present.

Interactions

Drug interactions with clomiphene (detailed information) Prescription and over-the-counter medications, vitamins, and herbal products, among others, may interact with clomiphene. Any new or discontinued medications should be disclosed to all of your healthcare providers.

Contraindications

Pelvic and abdominal pain Blurring or other visual side effects could happen throughout or right after clomiphene therapy. The usual maximum number of treatment cycles for clomiphene is six. Until you know how clomiphene affects you, avoid operating heavy machinery or driving. Clomiphene should not be taken if you have any of the following conditions: an allergy to clomiphene or any of its ingredients; a pregnancy; liver disease; abnormal uterine bleeding; ovarian cysts; uncontrolled thyroid or adrenal dysfunction. Clomiphene may also make you feel lightheaded or dizzy. Inform your doctor if any visual symptoms occur while using clomiphene. Ovarian cancer risk may rise with long-term clomiphene use. a number of births. Ovarian cancer. Ovarian enlargement may occur during or shortly after therapy with clomiphene. Serious side effects have been reported with clomiphene including the following: Visual symptoms. Talk to your doctor about the risks of taking this medication. There is an increased chance of multiple pregnancies when taking clomiphene. Inform your doctor right away if you experience any abdominal or pelvic pain, weight gain, discomfort, or bloating after taking clomiphene to reduce the risks of ovarian enlargement. Visual symptoms can increase the risk of operating machinery or driving a car, especially in situations with varying lighting.

Is clomiphene an anti androgen?

Clomifene has no apparent progestational, androgenic, or antrandrogenic effects and does not appear to interfere with pituitary-adrenal or pituitary-thyroid function. Based on early studies with 14 C-labeled clomifene, the drug was shown to be readily absorbed orally in humans.

What is the mechanism of action of clomiphene?

How does Clomiphene Citrate work? Clomiphene triggers the brain's pituitary gland to secrete an increased amount of follicle stimulating hormone (FSH) and LH (luteinizing hormone). This action stimulates the growth of the ovarian follicle and thus initiates ovulation.

What does clomiphene citrate do?

Clomiphene is used to induce ovulation (egg production) in women who do not produce ova (eggs) but wish to become pregnant (infertility). Clomiphene is in a class of medications called ovulatory stimulants. It works similarly to estrogen, a female hormone that causes eggs to develop in the ovaries and be released.

When should I take Clomid to get pregnant?

It is started on day 2 of the menstrual cycle (day 1 is the day you wake up bleeding) and initially a 50 mg tablet is taken once a day for 5 days. To help you remember to take Clomid, take it around the same time every day. Ovulation usually occurs 5-12 days after the last Clomid tablet.

Is clomiphene an estrogen agonist?

Clomiphene citrate (CC) is known to possess dual actions as an estrogen agonist and an estrogen antagonist.

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Testimonials
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Extk Apr 28, 2010, 12:24:47 AM

HPLC analysis revealed that the reaction had proceeded but not to completion. Concentrated sulfuric acid (HS0, 0.96 mL, 18.1 mmol) was added at a rate such that the internal temperature did not exceed 5 °C. batch high pressure chromatography or moving bed chromatography) using the same solvent as used in steps 1 and 2 (here DCM) in order to separate the cis- and trans-clomiphene isomers. 2-{4-[2-chloro-l,2- diphenylvinyl]phenoxy}-N,N-diethylethanamine (clomiphene -1.8:1 E:Z mixture) (8) was obtained. The hydrochloride salt was converted to the free base by addition of saturated aqueous bicarbonate solution.

solde9 Jan 2, 2013, 12:27:46 PM

Fertility drugs, though crucial to some fertility treatments, are extremely expensive and may not be covered by health insurance policies. There are multiple means of conception via fertility treatments. This allows the hypothalamus and pituitary gland to release reproductive hormones. What some men and women do not understand is the egg harvesting process and just how much goes into maturing multiple eggs and ensuring those eggs are ready for harvest at just the right time. Fertility drugs play a huge part in the entire fertility treatment process.

Youri van Bockstaele Jan 4, 2017, 7:47:59 PM

Clomiphene can help women who don't ovulate get pregnant by stimulating the ovaries to produce an egg and ovulate. • Quiz: Is Your Fertility Affected By Stress? A: Clomid, or Clomiphene Citrate (the brand names are Clomid and Serophene), has been on the market for over 25 years. This is turn causes the follicle to grow, it triggers the LH surge and thus induces ovulation.

Terrence Brannon Feb 2, 2022, 3:25:20 AM

Some studies show an increase in the chance for miscarriage in people with PCOS, while others attribute the increase to other factors like being overweight or obese, increased age, or use of fertility treatments (5,6,21,22,23). Metformin is a medication that makes it easier for the body to use the insulin it makes, decreasing the amount of insulin in the bloodstream. Ovulation (the release of an egg from the ovary) typically happens about once a month. Losing weight takes time, but even small changes can make a difference. Ovulation is likely to occur 13-15 days before the start of the next period (15).

Aelita Styles Oct 28, 2020, 7:52:57 PM

The reaction was again assayed by HPLC and an additional 0.058 equivalents of N-chlorosuccinimide (131 mg, 0.98 mmol) was added and the solution stirred for an additional 4 hours. Step 2- Synthesis of 2-|4-r2-chloro-L2-diphenylvinyl1phenoxyl-N,N- diethylethanamine 8 The solution of 2-{4-[(Z)-l,2-diphenylvinyl]phenoxy}-N,N-diethylethanaminium hydrogen sulfate (7.94 grams) in methylene chloride obtained in step 1 is stirred at room temperature and treated with N-chlorosuccinimide (2.37 g, 17.7 mmol, 1.05 equivalents) in a single portion and left to stir at room temperature for 12 hours. Trans-clomiphene is preferably eluted using a solvent suitable for recrystallization. The reaction yielded 6.86 grams of 2-{4-[2-chloro-l,2-diphenylvinyl]phenoxy}-N,N- diethylethanamine (8).

tinydynamite Dec 7, 2010, 7:41:03 AM

You can pay for your purchase through various methods, including PayPal and Bitcoin. It is to be noted that clomiphene citrate (Clomid) is an FDA-approved treatment for female infertility. [R] In a 2013 phase IIB human study, researchers noted a sustained increase in testosterone levels among the men in enclomiphene- and testosterone-treatment groups at three months of treatment. It should only be handled by qualified professionals and shouldn’t be used for veterinary or human use.

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