Side effects
If any of the following apply to you: For medical guidance on side effects, contact your doctor. (More information) Clarithromycin side effects The following are typical side effects of clarithromycin: If you experience symptoms of an allergic reaction to clarithromycin, such as hives, difficulty breathing, swelling in your face or throat, or a severe skin reaction, such as fever, sore throat, burning in your eyes, skin pain, or a red or purple skin rash that spreads and results in blistering and peeling, seek emergency medical attention. If you've ever experienced heart issues, taking clarithromycin may result in a heart attack or stroke years later. A life-threatening fast heart rate and other heart rhythm side effects may be more common in older adults. If you experience sudden numbness or weakness on one side of your body, chest pain that radiates to your jaw or shoulder, difficulty breathing, slurred speech, or difficulty speaking, seek medical attention right away. There may be other side effects; this is not a comprehensive list. You can contact the FDA to report side effects at 1-800-FDA-1088. Symptoms of liver problems include fatigue, loss of appetite, upper stomach pain, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes), while kidney problems include little to no urination, swelling in your feet or ankles, feeling exhausted or short of breath. stomach pain, nausea, vomiting; diarrhea; or unusual or unpleasant taste in your mouth.
Interactions
Absorption is boosted by eating. Take with food.
Contraindications
Ask your pharmacist for a list of the ingredients and let your doctor know if you're taking cisapride (Propulsid; not available in the U.S.), colchicine (Colcrys, Mitigare), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), lomitapide (Juxtapid), lovastatin (in Ad Inform your doctor and pharmacist if you are allergic to clarithromycin, azithromycin (Zithromax, Zmax), erythromycin (E.E.S., Eryc, Erythrocin, PCE, and others), telithromycin (not sold in the United States; Ketek), any other medications, or any of the components found in clarithromycin preparations before taking clarithromycin. Inform your doctor if you have or have ever had jaundice (yellowing of the skin or eyes) or other liver problems while taking clarithromycin. If you are taking one or more of these medications, your doctor will likely advise you not to take clarithromycin. Inform your doctor and pharmacist of all prescription and non-prescription drugs, vitamins, dietary supplements, and herbal products you are currently taking or plan to take. Your doctor will likely advise you not to take clarithromycin.
Therefore, children under 12 years of age should use clarithromycin pediatric suspension The dosage of clarithromycin depends on the clinical condition of the patient and has to be defined in any case by the physician. Caution is required when administering clarithromycin to children with lesser degrees of renal or hepatic insufficiency. The usual duration of treatment is 5 to 10 days depending on the pathogen involved and the severity of the condition. For some children, depending on body weight, it may be more appropriate to administer the 125mg/ 5ml oral suspension. Clarithromycin 250 mg/5 ml Oral Suspension may be given without regard to meals, as food does not affect the extent of bioavailability.
As with other strong CYP3A4 inhibitors, Clarithromycin should not be used in patients taking colchicine (see sections 4.4 and 4.5). Clarithromycin should not be given to patients with history of QT prolongation (congenital or documented acquired QT prolongation) or ventricular cardiac arrhythmia, including torsades de pointes (see sections 4.4 and 4.5). Hypersensitivity to macrolide antibiotic drugs or to any of the excipients listed in section 6.1.
It works by targeting certain proteins on the cancer cells and stops them from growing. The standard treatment for these patients is chemotherapy combined with targeted therapy. However, treatment with panitumumab leads to skin side effects, such as rash, in most patients. Chemotherapy with panitumumab has been shown to improve survival in patients with mCRC.
Such drugs may include amiodarone, procainamide, pimozide, quinidine, sotalol etc. Depending on its concentration, it acts either as bacteriostatic or bactericidal. Contraindicated in patients allergic to clarithromycin or other macrolide antibiotics. They penetrate bacterial cell wall, reversibly binds to domain V of 23S ribosomal RNA of 50S ribosomal subunit of bacteria and inhibits protein synthesis by inhibiting translocation step. In treatment of H. pylori infection, uncomplicated infection of skin and skin structure, bartonella infection, early Lyme disease.