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Clarithromycin
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clarithromycin drug class

Oral macrolide antibiotic that penetrates lung tissue and macrophages more deeply than erythromycin. Used for respiratory tract infections, STDs, otitis media, and MAC in AIDS patients.

Other names for this medication:
Biaxin, Omeclamox, Biaxin Bid, Prevpac

Similar Products:
Norfloxacin, Ethionamide, Metronidazole, Amoxil, Tetracycline, Levoflox, Cipro, Zyvox, Cenmox, Ethambutol, Chloromycetin, Keflex, Cefdinir, Omnicef, Levaquin, Vibramycin

Description

During translation and protein synthesis, binding prevents peptidyl transferase activity and obstructs amino acid translocation. Clarithromycin may be bacteriostatic or bactericidal depending on the organism and drug concentration. An antibiotic called clarithromycin, a semi-synthetic macrolide derived from erythromycin, prevents bacteria from producing proteins by attaching to their 50S ribosomal subunit.

Dosage

Other infections that can be treated with clarithromycin include pertussis, whooping cough, cat scratch disease, cryptosporidiosis, and Lyme disease, which can occur after a tick bite. There are three oral dosage forms of clarithromycin: tablets, long-acting extended-release tablets, and suspensions (liquids). Never take it in larger or smaller amounts or more frequently than directed by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. Your infection might not be completely treated and the bacteria might develop antibiotic resistance if you stop taking clarithromycin too soon or skip doses. If your symptoms do not improve or get worse, call your doctor. When patients are undergoing dental or other procedures, it is occasionally used to prevent heart infections. For an even distribution of the medication, thoroughly shake the suspension before each use. Avoid chewing, crushing, or splitting the long-acting tablets; instead, swallow them whole. Take clarithromycin every day at about the same time(s). Follow the medication instructions exactly when taking clarithromycin. Regardless of whether you feel better, continue taking clarithromycin until the medication is finished. When using this medication to treat your condition, discuss any potential risks with your doctor. The extended-release tablet is usually taken with food every 24 hours (once a day) for 7 to 14 days. For 7 to 14 days, the regular tablet and liquid are typically taken every 8 to 12 hours (twice daily) with or without food. Inquire with your doctor or pharmacist for more details if you believe this medication may be prescribed for other purposes. Maintain your regular diet unless your doctor instructs you otherwise. You should begin to feel better during the first few days of treatment with clarithromycin. Depending on your condition, your doctor might advise you to take clarithromycin for a longer period of time.

Missed dose

To make up for a missed dose, do not take a second one. However, if it is almost time for the next dose, skip the missed dose and continue your regular dosing schedule. As soon as you realize you missed a dose, take it.

Overdose

If you take too much clarithromycin, call your doctor or the nearest poison control center right away, or go to the hospital for emergency care.

Storage

Away from children's reach. Store away from light and moisture in a cool, dry area. The reconstituted suspension must be used within seven days if kept at room temperature and within fourteen days if kept in a refrigerator.

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Side effects

If any of the following apply to you: For medical guidance on side effects, contact your doctor. (More information) Clarithromycin side effects The following are typical side effects of clarithromycin: If you experience symptoms of an allergic reaction to clarithromycin, such as hives, difficulty breathing, swelling in your face or throat, or a severe skin reaction, such as fever, sore throat, burning in your eyes, skin pain, or a red or purple skin rash that spreads and results in blistering and peeling, seek emergency medical attention. If you've ever experienced heart issues, taking clarithromycin may result in a heart attack or stroke years later. A life-threatening fast heart rate and other heart rhythm side effects may be more common in older adults. If you experience sudden numbness or weakness on one side of your body, chest pain that radiates to your jaw or shoulder, difficulty breathing, slurred speech, or difficulty speaking, seek medical attention right away. There may be other side effects; this is not a comprehensive list. You can contact the FDA to report side effects at 1-800-FDA-1088. Symptoms of liver problems include fatigue, loss of appetite, upper stomach pain, dark urine, clay-colored stools, and jaundice (yellowing of the skin or eyes), while kidney problems include little to no urination, swelling in your feet or ankles, feeling exhausted or short of breath. stomach pain, nausea, vomiting; diarrhea; or unusual or unpleasant taste in your mouth.

Interactions

Absorption is boosted by eating. Take with food.

Contraindications

Ask your pharmacist for a list of the ingredients and let your doctor know if you're taking cisapride (Propulsid; not available in the U.S.), colchicine (Colcrys, Mitigare), dihydroergotamine (D.H.E. 45, Migranal), ergotamine (Ergomar, in Cafergot, in Migergot), lomitapide (Juxtapid), lovastatin (in Ad Inform your doctor and pharmacist if you are allergic to clarithromycin, azithromycin (Zithromax, Zmax), erythromycin (E.E.S., Eryc, Erythrocin, PCE, and others), telithromycin (not sold in the United States; Ketek), any other medications, or any of the components found in clarithromycin preparations before taking clarithromycin. Inform your doctor if you have or have ever had jaundice (yellowing of the skin or eyes) or other liver problems while taking clarithromycin. If you are taking one or more of these medications, your doctor will likely advise you not to take clarithromycin. Inform your doctor and pharmacist of all prescription and non-prescription drugs, vitamins, dietary supplements, and herbal products you are currently taking or plan to take. Your doctor will likely advise you not to take clarithromycin.

What are the most common side effects of clarithromycin?

Diarrhea, nausea, vomiting, headache, and changes in taste may occur. If any of these effects persist or worsen, tell your doctor or pharmacist promptly.

What are clarithromycin used to treat?

Clarithromycin is used to treat certain bacterial infections, such as pneumonia (a lung infection), bronchitis (infection of the tubes leading to the lungs), and infections of the ears, sinuses, skin, and throat.

How do you take clarithromycin tablets?

Take this medication by mouth with or without food as directed by your doctor, usually every 12 hours. If stomach upset occurs, you may take it with food or milk. For the best effect, take this antibiotic at evenly spaced times. To help you remember, take this medication at the same time(s) every day.

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Testimonials
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William Freeland Feb 6, 2021, 11:13:25 AM

Therefore, children under 12 years of age should use clarithromycin pediatric suspension The dosage of clarithromycin depends on the clinical condition of the patient and has to be defined in any case by the physician. Caution is required when administering clarithromycin to children with lesser degrees of renal or hepatic insufficiency. The usual duration of treatment is 5 to 10 days depending on the pathogen involved and the severity of the condition. For some children, depending on body weight, it may be more appropriate to administer the 125mg/ 5ml oral suspension. Clarithromycin 250 mg/5 ml Oral Suspension may be given without regard to meals, as food does not affect the extent of bioavailability.

Sari Aug 2, 2013, 9:47:32 PM

As with other strong CYP3A4 inhibitors, Clarithromycin should not be used in patients taking colchicine (see sections 4.4 and 4.5). Clarithromycin should not be given to patients with history of QT prolongation (congenital or documented acquired QT prolongation) or ventricular cardiac arrhythmia, including torsades de pointes (see sections 4.4 and 4.5). Hypersensitivity to macrolide antibiotic drugs or to any of the excipients listed in section 6.1.

ruebe Nov 22, 2016, 8:29:47 AM

It works by targeting certain proteins on the cancer cells and stops them from growing. The standard treatment for these patients is chemotherapy combined with targeted therapy. However, treatment with panitumumab leads to skin side effects, such as rash, in most patients. Chemotherapy with panitumumab has been shown to improve survival in patients with mCRC.

flycatdeng Jan 16, 2013, 6:19:11 AM

Such drugs may include amiodarone, procainamide, pimozide, quinidine, sotalol etc. Depending on its concentration, it acts either as bacteriostatic or bactericidal. Contraindicated in patients allergic to clarithromycin or other macrolide antibiotics. They penetrate bacterial cell wall, reversibly binds to domain V of 23S ribosomal RNA of 50S ribosomal subunit of bacteria and inhibits protein synthesis by inhibiting translocation step. In treatment of H. pylori infection, uncomplicated infection of skin and skin structure, bartonella infection, early Lyme disease.

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