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chloramphenicol injection uses

Detailed drug Information for chloramphenicol Oral, Intravenous, Injection. contains well-known brand names, drug descriptions, precautions, side effects, and dosing data.

Other names for this medication:
Chloromycetin

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Metronidazole, Norfloxacin, Clindamycin, Amoxil, Azee, Vantin, Cefdinir, Sumycin, Cenmox, Acillin, Macrodantin, Omnicef, Macrobid, Roxithromycin, Furadantin

Description

The lipid-soluble nature of chloramphenicol enables it to permeate bacterial cell membranes. It then forms a reversible bond with the L16 protein of the 50S subunit of bacterial ribosomes, preventing amino acid transfer to growing peptide chains (possibly by inhibiting peptidyl transferase activity), preventing the formation of peptide bonds, and subsequently inhibiting protein synthesis.

Dosage

Carefully adhere to the instructions on your prescription label. Exactly as directed by your doctor, take chloramphenicol. The Chloramphenicol dosage your doctor prescribes will depend on the following factors (use any or all that apply): the condition being treated, any other medical conditions you have, any other medications you take, how you react to this medication, your weight, height, age, and gender. Chloramphenicol is available in the following doses: Chloramphenicol 1000 mg Injectable Powder for Injection, Chloramphenicol 250 mg Oral Capsule, Chloramphenicol

Missed dose

Do not take two doses at once. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Take your missed chloramphenicol dose as soon as you remember.

Storage

Comprehensive dosage details for chloramphenicol Do not keep outdated medicine or medicine no longer needed. Avoid freezing. Keep children's reach at a distance. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light.

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Side effects

A medication may also have some unintended side effects in addition to its desired effects. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Bloated abdomen drowsiness gray skin tone low body temperature uneven breathing unresponsiveness For medical advice about side effects, contact your doctor. If any of the following side effects appear, consult your doctor right away: Consult a medical professional if any of the following side effects persist, are bothersome, or if you have any questions about them: Side effects of chloramphenicol (more information) Confusion, delirium, or headache eye pain, blurred vision, or loss of vision numbness, tingling, burning pain, or weakness in the hands or feet skin rash, fever, or difficulty in breathing vomiting, nausea, or diarrhea Consult a medical expert if you experience any additional side effects. Not as typical More about chloramphenicol Side effects Drug interactions Dosage information During pregnancy or Breastfeeding Reviews (2) Pricing & coupons Drug class: miscellaneous antibiotics Patient resources Patient Information Other brands Chloromycetin, Chloromycetin Sodium Succinate Professional resources Prescribing Information Related treatment guides Bacterial Infection Brucellosis Anthrax Cholera Some patients may also experience unlisted side effects. Pale skin, a sore throat, fever, unusual bleeding or bruising, and unusual exhaustion or weakness (the aforementioned side effects may last for weeks or months after you stop taking chloramphenicol) Rare There could be some side effects, but they typically don't require medical attention. Stop taking chloramphenicol and get emergency help immediately if any of the following effects occur: As your body gets used to the medication, these side effects may go away during treatment. Call 1-800-FDA-1088 to report side effects to the FDA. in only infants

Interactions

In some circumstances, two different medications may be used together even though a potential interaction may occur, even though some medications should never be used together. Tolbutamide Ceftazidime Chlorpropamide Cyanocobalamin Cyclosporine Dicumarol Fosphenytoin Phenytoin Rifampin Rifapentine Tetanus Toxoid Because there could be interactions, some medications shouldn't be taken at or close to mealtimes or when consuming specific foods. Live Citalopram Tacrolimus Voriconazole Cholera Vaccine The use of your medication with food, alcohol, or tobacco should be discussed with a healthcare professional. Your doctor may alter the dosage or frequency of use of one or both medications if they are prescribed together. Your doctor might want to adjust the dose in these circumstances, or additional safety measures might be required. The interactions listed below have been chosen because of their potential significance; they are not, however, all-inclusive. There may also be interactions if you use tobacco or alcohol along with some medications. Using chloramphenicol with any of the following medicines is usually not recommended, but may be required in some cases. Although there may be a higher risk of some side effects when chloramphenicol is taken with any of the following medications, doing so may still be the best course of action for you. If you are taking any of the medications listed below while taking chloramphenicol, it is crucial that your healthcare provider be aware of this.

What is the drug chloramphenicol used for?

Chloramphenicol is used to treat serious infections in different parts of the body. It is sometimes given with other antibiotics. However, chloramphenicol should not be used for colds, flu, other virus infections, sore throats or other minor infections, or to prevent infections.

What infections does chloramphenicol treat?

This medication is used to treat bacterial eye infections. Chloramphenicol is an antibiotic that works by stopping the growth of bacteria. This medication treats only bacterial eye infections.

What bacteria does chloramphenicol treat?

PRESCRIBED FOR: Chloramphenicol treats various infections caused by susceptible strains of S. yphi, H. influenzae, E. coli, Neisseria species, Staphylococcus and Streptococcusspecies, Rickettsia, lymphogranuloma-psittacosis group of organisms, and other bacteria that cause bacteremia (bacteria in blood) and meningitis.

What type of bacteria is killed by chloramphenicol?

Chloramphenicol has an especially broad spectrum of activity against numerous aerobic bacteria, mycoplasma, chlamydial organisms, anaerobic bacteria, and even methicillin-resistant Staphylococci.

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Testimonials
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Neil Ticktin Dec 31, 2017, 4:13:24 AM

This poster was presented at the 2019 ASMS Conference on Mass Spectrometry and Allied Topics in Atlanta, GA. W e demonstrate a cost-effective UHPLC/CMS method for the analysis of chloramphenicol in milk with a detailed discussion of sensitivity, linear response range, carryover and robustness using the Advion expression Compact Mass Spectrometer (CMS) and Advion AVANT UHPLC System.

Mehul Chaudhary Dec 12, 2010, 12:18:59 PM

Drug is active concerning the strains resistant to penicillin, streptomycin, streptocides. Chloramphenicol – a bacteriostatic antibiotic of a broad spectrum of activity. Pharmacokinetics At properties of instillation of drug in an eye happens intraocular and partially system absorption. Reduces antibacterial effect of aminoglycosides, penicillin, polymyxin B, tetracyclines, cephalosporins, erythromycin.

user268722 Apr 5, 2022, 1:53:13 AM

Within the cell, it binds to the 50S Subunit of bacterial ribosomes and inhibits bacterial protein synthesis by preventing attachment of amino-acyl transfer RNA to its acceptor site on the ribosome, thus preventing peptide bond formation by peptidyl transferase. CAS number 56-75-7 • Molecular weight CHClNO = 323.1 • Assay > 98 % Bacteriostatic agent against gram-negative and gram-positive bacteria.

osxipro Jul 30, 2015, 2:02:03 AM

Due to resistance and safety concerns, Chloramphenicol is no longer a first-line agent for any indication in developed nations, although it is sometimes used topically for eye infections; nevertheless, the global problem of advancing bacterial resistance to newer drugs has led to renewed interest in its use. In low-income countries, chloramphenicol is still widely used because it is exceedingly inexpensive and readily available. Chloramphenicol is considered a prototypical broad-spectrum antibiotic, alongside the tetracyclines.

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