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Chlorambucil
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chlorambucil dose

Malignant lymphomas and chronic lymphocytic leukemia are treated with chlorambucil, a chemotherapy drug.

Other names for this medication:
Leukeran

Similar Products:
Capecitabine, Cyclophosphamide, Femara, Hydroxyurea, Nolvadex, Methotrexate, Ondansetron, Xeloda, Hydrea, Letrozole, Zofran

Description

(11th edition of the Merck Index) a nitrogen mustard alkylating substance used as antineoplastic therapy for a range of cancers and other diseases. It has been listed as a known carcinogen in the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), despite being less toxic than the majority of other nitrogen mustards.

Dosage

Chronic lymphocytic leukemia: 150 mcg/kg/day initially, up until the total leukocyte count reaches 10,000 microliter. 200 mcg/kg/day for 4 to 8 weeks for Hodgkin's disease. Low-dose intermittent treatment regimens for maintenance. Non-Hodgkin's lymphoma: 100-200 mcg/kg/day for 4-8 wk. Treatment may be resumed 4 wk after at a dose of 100 mcg/kg/day. A starting dose of 6–12 mg per day until leucopenia sets in, then 2–8 mg per day, is recommended for Waldenstrom's macroglobulinemia.

Missed dose

To make up for a missed dose, do not take a second one. To continue with your regular dosing schedule, skip the missed dose if it is almost time for the next one. As soon as you realize you missed a dose, take it.

Overdose

However, if overdose is thought to have occurred, get emergency medical help. An overdose is unlikely to happen if this medication is administered by a healthcare professional in a hospital setting. Call your doctor or the local poison control center right away if you take too much of this medication, or go to the hospital for immediate emergency care.

Storage

This medication should not, however, be flushed down the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for toddlers to open. Keep this medication tightly closed in the original container and out of the reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. It should be kept in the fridge. Talk to your pharmacist or contact your local garbage/recycling department to learn about take-back programs in your community. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

Get immediate emergency medical assistance if you experience any of the following allergic reactions: For medical guidance on side effects, call your doctor. Side effects of chlorambucil (more information) Additional negative (serious) side effects: The following should be reported immediately to your doctor: This is not a complete list of side effects and others may occur. What are some typical chlorambucil side effects? What are the serious (bad) side effects of chlorambucil? Contact the FDA at 1-800-FDA-1088 to report side effects. a seizure, any unusual lump or mass, severe diarrhoea or vomiting, a cough that is new or getting worse, signs of bone marrow suppression like lightheadedness, exhaustion, pale lips or fingernail beds, or signs of liver issues like a lack of appetite, pain in the upper right side of the stomach, dark urine, clay-colored stools, yellowing of the skin or eyes. An allergic reaction (difficulty breathing, swelling in your face or throat, hives) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling). nausea, vomiting, or diarrhea, white spots or sores on your lips, low blood cell counts, missed periods in women, bone marrow suppression, and mouth sores or patches.

Interactions

Beware of echinacea. Food co-administration reduces bioavailability. Keep your fluid intake high. In patients taking therapeutic immunosuppressants, echinacea should only be used sparingly, if at all. When using an immunosuppressant concurrently, keep an eye out for any decreased effectiveness. Take this with a full stomach.

Contraindications

Ask your pharmacist for a list of the ingredients. Inform your doctor and pharmacist of all other prescription and nonprescription drugs, vitamins, dietary supplements, and herbal products you currently use or intend to use. Let them know if you have ever taken chlorambucil before but your cancer did not respond to the medication. Before taking chlorambucil, let your doctor and pharmacist know if you are allergic to any of the medication's ingredients, other alkylating agents like bendamustine (Treanda), busulfan (Myleran, Busulfex), carmustine (BiCNU, Gliadel Wafer), cyclophosphamide (Cytoxan), ifosfamide (Ifex), lomustine (CeeNU), melphalan ( Tell your doctor if you've had radiation therapy or any other form of chemotherapy within the last four weeks. Tell your doctor if you've ever had seizures or a head injury. Tell your doctor if you're breastfeeding. Don't get any vaccinations without consulting your doctor. Your doctor will probably advise against taking chlorambucil.

What is chlorambucil used to treat?

Chlorambucil is used treat a certain type of chronic lymphocytic leukemia (CLL; a type of cancer of the white blood cells). Chlorambucil is also used to treat non-Hodgkin's lymphoma (NHL) and Hodgkin's disease (types of cancer that begin in certain white blood cells that normally fight infection).

How long do dogs live after chemotherapy?

The dog will not be cured by chemotherapy but may have its life prolonged from 2–24 months [12,13]. The dog may feel better, still suffering from the cancer, or it may suffer from the side effects of the treatment. Untreated dogs have an average survival time of 4–6 weeks [12].

Is Leukeran the same as chlorambucil?

Chlorambucil is a chemotherapy drug and is also known by its brand name Leukeran. It is used mainly to treat: chronic lymphocytic leukaemia (CLL) Non-Hodgkin lymphoma.

Who makes chlorambucil?

It is currently approved in over 100 countries, with most of the market share being held by pharmaceutical companies GlaxoSmithKline and Aspen, which co-market the drug under the trade name Leukeran.

Can chlorambucil cure cancer?

Chlorambucil is used to treat certain types of cancer of the blood and lymph nodes. This drug doesn't cure cancer, but it helps relieve its symptoms.

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Testimonials
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jisnelyn Sep 1, 2016, 9:37:30 PM

Tags: Library Item, Research, Treatment, Type of leukemia-Chronic lymphocytic leukemia (CLL) This study concluded that first dose infusion reactions with obinutuzumab can be reduced by using chlorambucil first and by using a very slow initial obinutuzumab dose. This study was based on medical records and included a very small number of participants.

KvanteTore Mar 27, 2011, 10:46:52 PM

With a median follow-up of 46.9 months, the efficacy and safety of acalabrutinib plus obinutuzumab and acalabrutinib monotherapy were maintained with low rates of treatment discontinuation. No new safety signals were observed with acalabrutinib-containing treatment with longer-term follow-up. ELEVATE-TN is a phase 3, randomized, multicenter, open-label study (NCT02475681) that enrolled patients aged ≥65 years, or 18–65 years with comorbidities (Cumulative Illness Rating Scale-Geriatric score >6, creatinine clearance 30–69 mL/min by Cockcroft-Gault), who had TN CLL or SLL requiring treatment, Eastern Cooperative Oncology Group performance status score of ≤2, and adequate hematologic, hepatic, and renal function [9].

donna woodall Jun 15, 2017, 7:29:21 PM

In comparison, 26% of people taking chlorambucil had the same result. Indolent B-cell NHL is a type of blood cancer that’s slow growing (indolent). Bendeka comes as a solution that’s available in one strength: 100 mg/4 mL. (With an IV infusion, the drug is injected into your vein over a period of time.)

fikkatra May 8, 2015, 7:12:34 PM

Chronic lymphocytic leukaemia (CLL) is a white blood cell cancer that originates in the bone marrow and spreads to other parts of the body. The study also found that approximately 27.8% of people who received Gazyva in combination with chlorambucil achieved a complete response compared to 0.9% with chlorambucil alone. Patients administered with Gazyva plus chlorambucil exhibited a 75.9% overall response rate compared to 32.1% with chlorambucil alone.

Mason Kane Jul 13, 2019, 6:00:26 AM

GAZYVA (obinutuzumab), in combination with bendamustine followed by GAZYVA monotherapy, is indicated for the treatment of patients with follicular lymphoma (FL) who relapsed after, or are refractory to, a rituximab-containing regimen. Indications GAZYVA (obinutuzumab), in combination with chemotherapy followed by GAZYVA monotherapy in patients achieving at least a partial remission, is indicated for the treatment of adult patients with previously untreated stage II bulky, III or IV follicular lymphoma (FL). GAZYVA(obinutuzumab), in combination with chlorambucil, is indicated for the treatment of patients with previously untreated chronic lymphocytic leukemia (CLL).

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