Side effects
Side effects from cephalexin are possible. Call your doctor right away if you experience any of the following symptoms, or seek emergency medical attention if you do: extreme fatigue, agitation, headache joint pain, watery or bloody stools, stomach cramps, or fever during treatment or for up to two or more months after stopping treatment, rash, itching, and swelling of the face, throat, tongue, lips, and eyes, difficulty breathing, or rectal or genital itching. Tell your doctor if any of these symptoms are severe or persistent, including: dizziness, extreme fatigue, agitation, confusion, headache, joint pain, watery or bloody stools, stomach cramps, fever, rash, itching, hives, swelling of the face, throat, tongue, lips, and eyes, difficulty breathing or swallowing, and a return of fever.
Interactions
Cephalexin drug interactions (more detail) Not all possible drug interactions are covered in this list. Cephalexin may interact with other medications, including prescription and OTC drugs, vitamins, and herbal remedies. Tell your doctor about all your other medicines, especially: This isn't a comprehensive list. or probenecid; metformin.
Contraindications
The "bad" bacteria C. difficile can lead to diarrhea. seizures linked to patients with impaired kidney function Hypersensitivity reaction: Cephalexin may cause an allergic reaction. These are just a few of the serious side effects that have been reported. Symptoms of an allergic reaction to cephalexin include: skin rash itching hives difficulty breathing or swallowing sore throat vaginal infections dizziness fatigue headache agitation confusion hallucinations joint pain Clostridium difficile associated diarrhea: Cephalexin and other antibiotics can kill the “good” bacteria in the colon leading to a growth of C. difficile bacteria. Inform your doctor if you are allergic to cephalosporin antibiotics like cephalexin (Keflex) and cefuroxime (Ceftin) or penicillin antibiotics like ampicillin and moxicillin (Moxatag).
Dosing: Adult Usual dosage range: Oral: 250 to 1,000 mg every 6 hours or 500 mg every 12 hours (maximum: 4 g/day). Severe infection (eg, bone and joint infections): Oral: 75 to 100 mg/kg/day divided every 6 to 8 hours; maximum daily dose: 4,000 mg/day. Impetigo (staphylococcus or streptococcus): Note: Do not use if MRSA is suspected or confirmed.
Fluoroquinolones have neuromuscular blocking activity and can worsen muscle weakness in individuals with myasthenia gravis. Levaquin Levofloxacin as well as other antibiotics in the fluoroquinolone class of antibiotics have been associated with tendinitis and even rupture of tendons, particularly the Achilles tendon. The most frequently reported side effects are: Nausea or vomiting Diarrhea Headache Constipation Difficulty sleeping Dizziness Abdominal pain Rash Abdominal gas Itching What are the serious side effects (adverse effects) of levofloxacin Possible serious side effects of levofloxacin include: Peripheral neuropathy Central nervous system effects Hypoglycemia Hyperglycemia Clostridium difficile-associated diarrhea Abnormal heart beats Liver dysfunction Sun sensitivity Other serious side effects and adverse events of levofloxacin include: Levofloxacin should be used with caution in patients with central nervous system diseases such as seizures, because rare seizures have been reported in patients receiving Levaquin. Patients taking Levofloxacin can develop sensitivity of the skin to direct sunlight (photosensitivity) and should avoid exposure to sunlight or use sunblock. Individuals who are allergic to penicillin may also be allergic to cephalexin.
You must not continue if something is bothering you. You can be assured that all kinds of bacterial infections starting from pneumonia to Urinary Tract Infection can get treated with this medication. • Take this tablet orally with or without food every day or as prescribed by your doctor. This is useful for infections in tonsilitis, middle ear and more that can affect largely if not treated well. • If you are suffering from intestinal conditions, consult a doctor before taking this penicillin-like antibiotic.
References: (Note: Direct article downloads and article requests require a login ID with the BC College of Physicians website) [1] Moellering, RC Jr. Clin Infect Dis 2008:46:1032-7. Now, when I see a patient like the woman in this case, I incise and drain the abscesses and prescribe septra 1 DS tablet po bid and cephalexin 500 mg po qid for 5-14 days. Think of ca-MRSA in any patient presenting with an abscess and associated cellulitis. Many doctors, therefore, will prescribe both cephalexin to cover Group A Streptococcus, as well as septra or doxycycline to cover the ca-MRSA. In these cases, ca-MRSA should be covered empirically, but Group A Streptococcus should be covered as well.
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