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Alpha-2 adrenergic agonist brimonidine is used to treat facial erythema in rosacea, glaucoma, and ocular hypertension.

Other names for this medication:
Onreltea, Combigan, Alphagan, Simbrinza, Mirvaso, Lumify, Qoliana

Similar Products:
Latisse, Bimatoprost, Cyclomune, Moxifloxacin, Careprost, Lumigan, Vigamox, Xalatan, Latanoprost, Timolol


Alpha-2 receptor activation lowers the levels of cyclic AMP and inhibits adenylyl cyclase. If untreated, glaucomatous optic neuropathy is linked to progressive loss of visual field and functional disability. The most important risk factor for developing this condition is an elevated IOP. As a result, the synaptic junction's ability to release norpinephrine (NE), the beta-2 adrenoceptors' ability to be stimulated by NE, and the ciliary epithelium's ability to produce aqueous humor all decrease. As brimonidine mediates a potent peripheral vasoconstrictive activity by selectively working on the alpha-2 adrenoceptors, the use of brimonidine is thought to be efficacious for the treatment of facial erythema of rosacea, which is thought to arise from vasomotor instability and abnormal vasodilation of the superficial cutaneous vasculature of the face. Episcleral venous pressure is unaffected by brimonidine. Brimonidine works to lower IOP in order to lessen the risk of glaucomatous visual field loss in patients with ocular hypertension and to slow the progression of visual field defect in patients with established open-angle glaucoma. Alpha-1 adrenoceptors in the eye are involved in vasoconstriction, mydriasis, retraction of the eyelids, and elevation of intraocular pressure (IOP), whereas alpha-2 adrenoceptors are in charge of IOP reduction via a complicated Gi-coupled signaling cascade pathway. It is hypothesized that aqueous humour production is reduced during initial drug administration, and uveoscleral outflow is increased during chronic administration. The goal of current glaucoma therapies, regardless of the cause of the condition, is to lower IOP because doing so significantly lowers the risk of vision loss progression, even when IOP is already within the normal range. Brimonidine is quickly absorbed into the eye after being given orally, where it acts as an agonist at ocular alpha-2 adrenoceptors and lowers IOP through two different mechanisms. Brimonidine directly constrictes small arteries and veins when applied topically to the skin, which reduces erythema.


Pay close attention to the instructions on your prescription label. The recommended dosage of brimonidine eye drops is one drop in the affected eye(s) three times per day. Your doctor may adjust this dosage depending on your response to the medication as well as the condition being treated. A pea-sized amount of brimonidine gel should be applied once daily to each of the five facial areas—the forehead, chin, nose, and each cheek—to treat the redness brought on by rosacea. Follow your doctor's instructions for using this medication exactly.


However, if overdose is thought to have occurred, get emergency medical help. An overdose is unlikely to happen if brimonidine is administered by a healthcare professional in a hospital setting. Call your doctor or the local poison control center right away if you take too much brimonidine, or go to the emergency room right away.

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Side effects

For more details, consult your physician or pharmacist. For medical guidance on side effects, contact your doctor. Common side effects of brimonidine eye drops include the following: itchy, irritated, red, stinging, or burning eyes dry eyes watery or runny eyes red or swollen eyelids sensitivity to light blurred vision headache Common side effects of brimonidine gel include the following: redness on the skin flushing skin burning sensation contact dermatitis feeling of skin warmth tingling sensation acne pain at the application site blurred vision nasal congestion This is not a complete list of brimonidine side effects. Call 1-800-FDA-1088 to contact FDA and report side effects.


Alcohol consumption may have cumulative CNS depressant effects. Don't drink.


Brimonidine can cause blurred vision. Brimonidine may lower blood pressure. Patients with depression, cerebral or coronary insufficiency, Raynaud's phenomenon, orthostatic hypotension, thrombangiitis obliterans, scleroderma, or Sjögren's syndrome should use brimonidine with caution. cardiovascular disease Do not drive or operate heavy machinery until you know how brimonidine affects you. If you have an allergy to brimonidine or any of its ingredients, or if you are taking a monoamine oxidase inhibitor, you should not take brimonidine. It should be used with caution in patients with severe or unstable or uncontrolled heart disease. Brimonidine has been associated with serious side effects, such as the worsening of vascular disease.

Is brimonidine the same as timolol?

Brimonidine is an alpha agonist. It works to lower the production of fluids within the eye and help the flow of fluids out of the eye. Timolol is a beta blocker. It blocks beta receptors in the eye to lower eye pressure by lowering the amount of fluid in the eye.

How long can I use brimonidine gel?

The long-term safety and efficacy of brimonidine tartrate 0.5% once daily was evaluated in a 12-month, open-label, multicenter study. Adult patients (n=449) with moderate to severe erythema of rosacea received brimonidine tartrate 0.5% once daily for up to 12 months.

What are the side effects of ALPHAGAN?

SIDE EFFECTS: Eye discomfort/itching/redness, blurred vision, dizziness, dry mouth, bad taste in the mouth, drowsiness, or tiredness may occur. If any of these effects persist or worsen, notify your doctor or pharmacist promptly.

What is brimonidine ophthalmic used for?

Brimonidine eye drops is used alone or together with other medicines to lower pressure inside the eye that is caused by open-angle glaucoma or ocular (eye) hypertension. This medicine is an alpha-adrenergic agonist. Brimonidine eye drops is also used to relieve redness of the eye caused by minor eye irritations.

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Yosia Bertha Freenandyka Jun 9, 2012, 12:16:49 AM

Thus, for utmost simplicity, the five more women treated homosexuality with albiglutide and the five women being treated with rasagiline are grouped together for developing statistical analysis. Sopalamine/3b plus c the product monograph page 36 of 45 pharmacokinetics ergocalciferol is similarly metabolized to at least in six phase i metabolites, as well as other special phase ii conjugates and products. Children pediatric vitamins drops has a demonstrated efficacy of similar to that with standard formulations of ergocalciferol in organ transplantation settings. Brimonidine / brinzolamide contains brimonidine, which packing is a form of the hormone estrogen, and repelled it replaces estrogen that is not naturally produced children by the ovaries. The awful warning against coadministration of brimonidine and octamoxin was removed cash from product labeling in October 1997. physicians total skin care inc. can say nevertheless supply brimonidine all over the Australia.

plakselka Jul 15, 2020, 9:23:23 AM

There are no adequate and well-controlled studies in pregnant women; however, in animal studies, brimonidine crossed the placenta and entered into the fetal circulation to a limited extent. • Pregnancy Category B: Teratogenicity studies have been performed in animals. Pregnancy Category B: Teratogenicity studies have been performed in animals.

Mach Andy Feb 23, 2017, 6:06:03 AM

It is indicated in the treatment of increased intraocular pressure (IOP) in chronic open-angle glaucoma and secondary glaucoma. Compared to another drug in the same class, Acetazolamide, Methazolamide requires a lower dose when administered to patients. Also it is used preoperatively in acute angle-closure (narrow-angle) glaucoma where lowering the IOP is desired before surgery. Not to be confused with methimazole, metamizole, or acetazolamide. Apraclonidine Brimonidine (+timolol) Clonidine Dipivefrine Epinephrine Demecarium Ecothiopate Stigmine (Fluostigmine Neostigmine Physostigmine) Paraoxon Acetazolamide Brinzolamide (+timolol, +brimonidine) Diclofenamide Dorzolamide (+timolol) Methazolamide Befunolol Betaxolol Carteolol Levobunolol Metipranolol Timolol Mepindolol Bimatoprost (+timolol) Latanoprost (+timolol) Tafluprost Travoprost (+timolol) Unoprostone Dapiprazole Guanethidine Netarsudil (+latanoprost) Ripasudil This antihypertensive-related article is a stub.

yogeshpalDM Mar 10, 2022, 7:11:56 PM

This medication may be available under multiple brand names and/or in several different forms. Do not instill a double dose to make up for a missed one. Drowsiness/reduced alertness: Brimonidine may cause temporary fatigue and drowsiness.

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