Information on baricitinib that has been reviewed by a doctor, including its uses, dosage, and instructions.
Other names for this medication:
In addition to or instead of other DMARDs, baricitinib may be used as monotherapy. For the treatment of moderate to severe atopic dermatitis in adult patients who are candidates for systemic therapy, baricitinib is indicated in Europe. Baricitinib is prescribed for the treatment of adult patients with moderately to severely active rheumatoid arthritis who have not responded well to one or more TNF blockers in the US and Europe. Baricitinib is also approved in the US to treat adults hospitalized with COVID-19 who require extracorporeal membrane oxygenation, non-invasive or invasive mechanical ventilation, or supplemental oxygen.
Information on the correct dosage of baricitinib Read all medication guides or instructions before using any of the products listed on your prescription label. Taking baricitinib can make these viruses more active or worsen them if you've ever had shingles (herpes zoster). Keep your items at room temperature away from heat and moisture. Use baricitinib as directed for the entire recommended period of time (typically for 14 days or until you are discharged from the hospital, whichever comes first). Follow the medication's directions to the letter. You could experience an increased risk of infections, including serious or fatal ones. With or without food, you can take baricitinib. While taking baricitinib for COVID-19, you must remain in a medically-supervised setting. You will need frequent medical tests. Your doctor may perform tests to make sure you do not have tuberculosis or other infections.
Never combine two doses at once. If you have time, take the medication as soon as you remember, but skip the missed dose if your next dose is almost due.
Call 1-800-222-1222 for poison help if you need immediate medical attention.
However, you should not flush this medication down the toilet. The best way to get rid of your medication is instead through a medication take-back program. All medications should be kept out of the sight and reach of children, as many containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for toddlers to open. Keep this medication out of the reach of children and tightly closed in the original container. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. It should not be kept in the bathroom. Store it at room temperature, away from sources of extreme heat and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. http://www.upandaway.org Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.
Side effects of baricitinib (in more detail) If you experience any of the following: For medical guidance on side effects, contact your doctor. Common side effects may include: Some baricitinib users have experienced heart attacks, strokes, or life-threatening blood clots. If you experience hives, difficulty breathing, swelling of your face, lips, tongue, or throat, stop taking baricitinib and seek emergency medical attention. Stop taking baricitinib and seek emergency medical attention if you have: There may be other side effects; this is not a comprehensive list. Call 1-800-FDA-1088 to report side effects to the FDA. nausea, shingles, cold symptoms like a sore throat, stuffy nose, or sneezing. fever, chills, night sweats, constant tiredness; wheezing, trouble breathing, severe or worsening cough; increased urination, pain or burning when you urinate; unexplained weight loss; lumps in your neck, armpits, or groin; signs of shingles--flu-like symptoms, tingly or painful blistering rash on one side of your body; a hole (perforation) in your digestive tract--fever, severe stomach pain, diarrhea or changes in bowel habits; or signs of hepatitis--loss of appetite, vomiting, stomach pain (upper right side), dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes). Sudden difficulty breathing; chest pain or pressure that may radiate to your jaw, shoulder, arms, or back; nausea, vomiting, cold sweat; a feeling of impending dizziness; weakness on one side of your body; slurred speech; drooping on one side of your mouth; or pain, swelling, or redness in an arm or a leg.
A high-fat meal can decrease the mean AUC and Cmax of baricitinib and delay Tmax, but not to a clinically singificant extent. Take with or without food.
Inform your doctor and pharmacist about all other prescription and over-the-counter drugs, vitamins, dietary supplements, and herbal products you are currently taking or intend to take, and ask for a list of the ingredients from your pharmacist. Be sure to mention the medications listed in the IMPORTANT WARNING section or the following: probenecid (Probalan, in Col-Probenecid). Inform your doctor and pharmacist if you have any drug allergies prior to taking baricitinib, as well as if you have any allergies to any of the ingredients in baricitinib tablets. Do not breastfeed while taking baricitinib. tell your doctor if you have recently received or are scheduled to receive any vaccinations. Avoid getting any shots while you are receiving treatment without first consulting your doctor. Call your doctor right away if you find out you're pregnant while taking baricitinib, and let them know if you're nursing. Tell your doctor if you have stomach pain that hasn't been diagnosed, if you have or have ever had ulcers (sores in the lining of your stomach or intestine), diverticulitis (swelling of the lining of the large intestine), anemia (a lower than normal number of red blood cells), or herpes zoster (shingles; a rash that can occur in people who have had chickenpox in the past).
Is baricitinib approved for alopecia areata?
The European Medicines Agency's (EMA) Committee for Medicinal Products for Human Use (CHMP) has recommended approval of baricitinib, a Janus kinase (JAK) inhibitor, for the treatment of adults with severe alopecia areata (AA).
Is baricitinib used for Covid?
The combination of baricitinib, an anti-inflammatory drug, and remdesivir, an antiviral, reduced time to recovery for people hospitalized with COVID-19, according to clinical trial results published in the New England Journal of Medicine.
What is the first drug that was approved by the FDA to treat COVID-19?
Remdesivir is the first drug approved by the FDA for treatment of hospitalized COVID patients over the age of 12.
Who can prescribe baricitinib?
Most people who benefit from this treatment will notice an improvement within the first few weeks of starting treatment, but further improvements may be seen over the first six months of treatment. Baricitinib can be prescribed by a consultant rheumatologist for adults with rheumatoid arthritis.
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