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baclofen dosing pediatrics

Avoid rapid drug withdrawal as it may result in severe and fatal adverse reactions. Skeletal muscle relaxant given orally and intravenously; a GABA derivative. used to treat spasticity in patients with MS and other spinal cord lesions; in some patients, it may improve bowel and bladder function.

Other names for this medication:
Lyvispah, Kemstro, Gablofen, Fleqsuvy, Ozobax, Lioresal

Similar Products:
Mestinon, Methocarbamol, Tizanidine, Robaxin

Description

Additionally, baclofen stimulates gastric acid secretion and mediates some antinociceptive effects. By inhibiting the release of pro-inflammatory cytokines from microglia and astrocytes and reducing oxidative stress in rats, baclofen exhibits anti-inflammatory and neuroprotective properties. Baclofen can cause ataxia, sedation with tolerance, somnolence, CNS depression, and respiratory and cardiovascular depression. Baclofen is an antispasmodic agent that induces muscle relaxation. In one cross-sectional study, intrathecal baclofen was superior to oral baclofen at reducing spinal cord-level spasticity. It reduces the release of excitatory neurotransmitters in the pre-synaptic neurons and stimulates inhibitory neuronal signals in the post-synaptic neurons. The most widely utilized form of baclofen is in oral formulations.

Dosage

Don't take it more often than directed or increase the dose. Avoid stopping this medication without first talking to your doctor. Use a proper measuring spoon; don't use a regular spoon. Observe your doctor's instructions exactly. Use a special measuring tool or spoon to precisely measure the dosage if you are taking the medication in liquid form. Additionally, you run the risk of experiencing withdrawal symptoms (like hallucinations and seizures) if you stop taking this medication abruptly. Before taking each dose, shake the bottle vigorously if your liquid form is a suspension. When this medication is abruptly stopped, some conditions might get worse. Take this medication by mouth with or without food as directed by your doctor, usually 3 times a day. If your condition doesn't improve or worsens, tell your doctor right away. If you experience withdrawal symptoms, contact your doctor or pharmacist right away. The dosage is determined by your health status and treatment response. Your doctor might lower your dose gradually to help prevent withdrawal. To help you remember, take it at the same times each day. Your doctor might advise you to start this medication at a low dose and gradually increase it in order to reduce your risk of experiencing side effects. Use this medication regularly to get the most benefit from it. If you've taken baclofen for a long time or in high doses, withdrawal is more likely to occur.

Missed dose

To make up for a missed dose, don't take a second one. If, however, it is almost time for the subsequent dose, skip the missed one and carry on with your regular dosing schedule. If you miss a dose, take it as soon as you remember.

Overdose

But if overdose is thought to have occurred, get emergency medical help. If this medication is administered by a healthcare provider in a medical setting, it is unlikely that an overdose will occur. If you take too much this medication, call your healthcare provider or local Poison Control Center, or seek emergency medical attention right away.

Storage

If you have any inquiries regarding your dosage form, speak with your pharmacist. Speak with your pharmacy or the neighborhood waste removal service. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Place nowhere near a bathroom. If you're taking this medication in liquid form, first determine whether the liquid is a suspension or not. Store the medication in the refrigerator in a tightly closed container away from light if your liquid form is not a suspension. If your liquid is a suspension, keep the bottle at room temperature, and after two months, throw away any unused liquid. Away from children and pets, keep all medications. Properly discard this product when it is expired or no longer needed. The tablet form of this medication should be kept at room temperature, away from moisture and light.

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Side effects

Baclofen side effects (more detail) If you experience any of the following: For medical advice about side effects, contact your doctor. Typical adverse reactions to baclofen include: If you experience any of the following symptoms of an allergic reaction to baclofen: hives; difficulty breathing; swelling of your face, lips, tongue, or throat, seek emergency medical attention. There may be additional side effects; this is not a comprehensive list. Call 1-800-FDA-1088 to contact FDA and report side effects. fatigue, weakness, drowsiness, dizziness, headache, insomnia, nausea, constipation, or the need to urinate more frequently than usual. Itching, tingling, or twitching in your hands, arms, feet, or legs; severe drowsiness; weak or shallow breathing; confusion; hallucinations; fever; or a seizure.

Interactions

Baclofen is prescribed for the following conditions: multiple sclerosis-related spasticity, flexor spasms with accompanying pain, clonus, and muscular rigidity, rheumatic disorders-related skeletal muscle spasms, spinal cord injuries, and other spinal cord diseases, cerebrovascular accidents, or neoplastic or degenerative brain diseases.

Contraindications

Appropriate laboratory tests should be performed periodically in patients with hepatic diseases or diabetes mellitus to ensure that no medicine induced changes in these underlying diseases have occurred. Baclofen has not significantly benefited patients with stroke. Patients with peptic ulcers, cerebral vascular diseases, or hepatic, renal, or respiratory failure should use baclofen with caution, whether they currently have them or have a history of them. Baclofen should be used with caution in these circumstances. Particularly in patients with cardiopulmonary disease and weak respiratory muscles, careful monitoring of cardiovascular and respiratory function is imperative. Neurogenic issues affecting bladder emptying may get better while taking Baclofen. Acute urine retention, however, is possible in patients with preexisting sphincter hypertonia. Baclofen may be used in patients with epilepsy and muscle spasticity if the proper precautions are taken and adequate anticonvulsive therapy is continued. For patients with impaired renal function or those undergoing chronic haemodialysis, lower doses (roughly 5 mg per day) ought to be used. After stopping Baclofen therapy or with an overdose, there may be a lowering of the convulsion threshold, and seizures have been documented. Spasticity patients should also be treated carefully and under close observation if they also have psychotic disorders, schizophrenia, depressive or manic disorders, or confusional states because these conditions may exacerbate each other. Additionally, these patients' tolerance for the medication has been poor.

What type of drug is baclofen?

Baclofen is in a class of medications called skeletal muscle relaxants. Baclofen acts on the spinal cord nerves and decreases the number and severity of muscle spasms caused by multiple sclerosis or spinal cord conditions. It also relieves pain and improves muscle movement.

What conditions does baclofen treat?

Baclofen is used to treat muscle spasms caused by certain conditions (such as multiple sclerosis, spinal cord injury/disease). It works by helping to relax the muscles.

What diseases is baclofen used for?

Baclofen is used to treat pain and certain types of spasticity (muscle stiffness and tightness) from multiple sclerosis, spinal cord injuries, or other spinal cord diseases. Baclofen is in a class of medications called skeletal muscle relaxants.

What drug class is baclofen?

Baclofen belongs to a class of drugs called Skeletal Muscle Relaxants.

Does baclofen make you sleepy?

Taking baclofen can make you feel sleepy and affect your concentration and focus. This is more likely to happen if you are over 65 or if you take baclofen with a full meal. Do not drink alcohol while taking this medication.

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Testimonials
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Mythoranium Jan 5, 2014, 12:17:16 AM

On average, the adolescent patients in the current analysis were exposed to a higher dose of baclofen and continued their other narcolepsy treatments as well. Traditional stimulants, including methylphenidate and amphetamines, are second- and third-line therapies. Thus, the beneficial responses reported may be related to the higher baclofen dose or to possible synergy with other therapies. The investigators studied the cases of 5 patients with narcolepsy associated with severe daytime sleepiness who had failed, had an inadequate response to, or had intolerable adverse effects associated with their first-line therapies. Evidence suggests that baclofen may offer sleep benefits by reducing sleep latency and increasing slow-wave sleep.The use of baclofen has also been shown to increase total sleep time — both rapid eye movement (REM) and non-REM sleep duration — and has been associated with a significant reduction in the time spent awake after sleep onset.

user504737 Oct 29, 2018, 7:44:20 AM

In addition to the risk of depressing brain function, the use of baclofen and tricyclic antidepressants (for example, amitriptyline [Elavil, Endep], doxepin [Sinequan, Adapin]) together may cause muscle weakness. Metaxalone may increase the sedative effects of alcohol and drugs that cause sedation, for example, benzodiazepines (Valium), antidepressants, opioids (morphine). Because baclofen can increase blood sugar, doses of antidiabetic drugs may need to be adjusted when baclofen is begun.

Lachlan Shoesmith Jan 31, 2021, 11:21:25 AM

During the pregnancy, this treatment should be used only when strongly necessary. The symptoms of overdose usually include chest pain, nausea, irregular heartbeat, and feeling light-headed or fainting. In case you notice the effects not listed here, contact your doctor or pharmacist. Store your medicines at room temperature between 68-77 degrees F (20-25 degrees C) away from light and moisture.

Stephanie Pratt Nov 9, 2019, 9:01:34 AM

Baclofen Oral Solution is also indicated in adults and children for the relief of spasticity of voluntary muscle arising from e.g. Baclofen Oral Solution is indicated in patients 0 to <18 years for the symptomatic treatment of spasticity of cerebral origin, especially where due to infantile cerebral palsy, as well as following cerebrovascular accidents or in the presence of neoplastic or degenerative brain disease. tumours of the spinal cord, syringomyelia, motor neurone disease, transverse myelitis, traumatic partial section of the cord.

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