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antabuse medications list

Antabuse interferes with the metabolism of alcohol and is used to treat chronic alcoholism. Learn about interactions, side effects, and indications.

Other names for this medication:
Disulfiram

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Description

A prescription drug called Antabuse is used to treat chronic alcoholism. For more information, speak with your doctor or pharmacist. Other prescriptions for this drug are possible.

Dosage

Pay close attention to the instructions on your prescription label. Take this medication exactly as your doctor has advised. The average maintenance dose is 250 mg daily. The recommended maintenance dose range of Antabuse for the treatment of chronic alcoholism is between 125 and 500 mg per day. The dose your doctor recommends may depend on the condition being treated, how you react to this medication, and other factors. As long as the patient hasn't socially recovered from alcohol abuse and is fully capable of maintaining permanent self-control, therapy may be continued.

Missed dose

If you remember right away, take the missed dose. Unless your doctor instructs you otherwise, take the remaining doses for the day at regularly spaced intervals.

Overdose

Call 1-800-222-1222 for poison help if you need immediate medical attention.

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Side effects

Even trace amounts of alcohol when taking antabuse can have negative effects. Call your doctor for medical advice about side effects. Drowsiness, headaches, fatigue, acne, changes in taste (metallic or garlic-like), impotence, skin rashes, and skin rash are some of the side effects that are frequently observed during the first two weeks of therapy. These side effects are typically mild and only last for a short period of time. See "Antabuse Precautions" for more information. Serious side effects have been reported with Antabuse. These side effects include: flushing of the face headache nausea vomiting chest pain weakness blurred vision mental confusion sweating choking breathing difficulty anxiety These effects start about 10 minutes after alcohol enters the body and last for at least an hour. Do not drink any alcoholic beverages while taking Antabuse, during the 12-hour window before you take your first dose, and for at least the first two weeks after you finish taking it. Ask your physician or pharmacist for more details as this is not a comprehensive list of Antabuse side effects. Call 1-800-FDA-1088 to report side effects to the FDA.

Interactions

Ask your doctor or pharmacist for more information. Tell your doctor right away if you take any of the following medications, which are not all of the possible Antabuse drug interactions. Amitriptyline (Elavil), anticoagulants (also known as "blood thinners") like warfarin (Coumadin, Jantoven), isoniazid metronidazole (Flagyl), phenytoin (Dilantin), or any over-the-counter medications that might contain alcohol. Tell your doctor about all the medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Contraindications

Driving and using large machinery shouldn't be done until you know how Antabuse affects you. If you have recently taken metronidazole, paraldehyde, alcohol, or medications containing alcohol such as cough syrups and tonics, have severe myocardial disease or coronary occlusion, have psychoses, or are allergic to Antabuse or any of its ingredients, you should not take Antabuse. Serious side effects have been reported with Antabuse including the following: Liver toxicity. Tell your doctor right away if you experience any of the following signs or symptoms of liver toxicity: excessive fatigue or weakness, loss of appetite, nausea, vomiting, yellowing of the skin or eyes, dark urine, and antabuse. Antabuse can also impair judgment and make you feel sleepy.

Is Antabuse still used?

Disulfiram For Alcoholism Treatment. Disulfiram (Tetraethylthiuram Disulfide or Antabuse) has been prescribed for the treatment of alcohol use disorders (AUDs) in the United States for more than 65 years and is currently used by more than 200,000 Americans.

What does the medication Antabuse do?

This medication is used along with counseling and support to treat alcoholism. Disulfiram works by blocking the processing of alcohol in the body. This causes you to have a bad reaction when you drink alcohol.

How long after Antabuse can you drink?

You really need to wait up to 14 days after your last dose of Antabuse to consume alcohol. Sometimes people will throw caution to the wind, and just go ahead and have a drink. For most people, this only happens one time. This is because drinking on Antabuse produces side effects that are pretty severe.

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Testimonials
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Dentogan Mar 23, 2010, 10:55:31 AM

This is what makes it so effective for alcoholics. People should be aware of the chance of gaining weight prior to starting this drug. The Disulfiram implant price is also quite comparable to the pill. For most people, this only happens one time.

argief Nov 17, 2010, 5:41:40 AM

Kudzu treatment also resulted in the number of sips and length of time for consuming each beer, as well as a decrease in the volume of each sip. For example, drowsiness and headaches are common side effects of Antabuse. Lukas SE, Penetar D, Berko J, Vicens L, Palmer C, Mallya G, Macklin EA, Lee, DYW. Alcoholism: Clinical & Experimental Research 2005: 29(5), 756-762. Currently, commonly prescribed anti-drinking drugs such as disulfiram (Antabuse), naltrexone (Revia and Vivitrol), and acamprosate (Campral), cause several side effects.

Caleth Jul 14, 2010, 2:20:47 PM

You may be asked to take several tablets a day during the first few days of treatment, but after this your dose will be reduced. If you have ever had an allergic reaction to a medicine. It is important that you have not drunk any alcohol for at least 24 hours before you take your first dose of disulfiram. Take disulfiram exactly as your doctor tells you to. It will give you a throbbing headache, a flushed face, and the sensation of having a 'thumping heart' (palpitations), and it will make you feel very sick.

Peyote Nov 8, 2012, 3:48:32 AM

"The current observation of 'one size does not fit all' (i.e., that a pharmacotherapy may constitute a useful adjunct therapy for some individuals but not for others) calls for caution when prescribing modafinil and strongly supports the potential of and the need for personalized medicine," added Schmaal. Modafinil also modulated brain activation in key brain regions directly involved response inhibition, but again, only in those patients with poor baseline response inhibition. It has also been shown to reduce impulsivity in some individuals with addictions, but these effects had not yet been studied in non-stimulant addictions like alcohol dependence.

stas44 Feb 17, 2022, 9:18:32 AM

Antabuse disrupts the body's processing of alcohol in the liver. A patient experiencing an disulfiram-ethanol reaction can develop a severe headache, difficulty in breathing, chest pains, vomiting, and a drop in blood pressure. She found that antabuse was effective in deterring drinking among alcoholics and went on to treat about 2,500 patients with it. Because each man experienced the same symptoms at the same time, the researchers concluded that the disulfiram, triggered by the alcohol, was responsible for the illness. Normally, certain enzymes (proteins produced by living organisms) break down alcohol into acetaldehyde, while other enzymes break acetaldehyde down into acetate (a salt of of clear, colorless organic liquid).

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