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zenatane vs isotretinoin

Information on the use, dosage, and precautions of isotretinoin (oral) that has been reviewed by a physician.

Other names for this medication:
Claravis, Zenatane, Accutane, Myorisan, Amnesteem, Clarus, Epuris, Sotret, Absorica

Similar Products:
Fluticasone, Bactroban, Prednisolone, Mometasone, Aziderm, Elimite, Fulvicin, Flutivate, Isotroin, Tretinoin, Adaferin, Melalite, Hydroquinone, Melacare, Erythromycin


Using retinoid derivatives of vitamin A, such as isotretinoin, to treat severe, resistant acne is becoming more and more popular. Isotretinoin is associated with major risks in pregnancy and is therefore only available under the iPLEDGE program in the United States. It was most frequently marketed under the now-discontinued brand name Accutane. On May 7, 1982, the FDA approved the first isotretinoin-containing product.


For more details, consult your physician or pharmacist. Do not chew, crush, or suck on the capsules. Do not take more or less of it or take it more often than prescribed by your doctor. Ask your doctor or pharmacist to explain any instructions on your prescription label that you are unsure about following. If you have any questions regarding how much isotretinoin to take, consult your doctor or pharmacist before proceeding. Isotretinoin comes as a capsule to take by mouth. Other skin conditions and some types of cancer have been treated with isotretinoin. For a period of 4 to 5 months, isotretinoin is typically taken twice daily with meals. You might need a few weeks or longer to experience isotretinoin's full benefits. Swallow the capsules whole with a full glass of liquid. Follow the isotretinoin directions exactly. Talk to your doctor about the possible risks of using this medication for your condition. This is typical and doesn't indicate that the medication isn't doing its job. Other prescriptions for this drug are possible. Keep eating the same way as usual unless your doctor instructs you otherwise. Even after your isotretinoin treatment is over, your acne may still get better. At the start of your isotretinoin treatment, your acne may get worse. Your doctor will likely start you on an average dose of isotretinoin and adjust it as needed based on how well you respond to it and any side effects you encounter.

Missed dose

Do not use two doses at one time. If you miss a dose, skip it and take your next dose at the scheduled time.


Call emergency services at 911 right away if the victim has fallen, experienced a seizure, is having trouble breathing, or cannot be roused. Call 1-800-222-1222 to reach the poison control hotline in the event of an overdose. You can find information online at Men should use condoms or refrain from sexual activity with their partners for a month after an overdose because isotretinoin may be present in the semen. The risks of continuing a pregnancy after an overdose should be discussed with doctors by expectant mothers. Symptoms of overdose may include the following: vomiting flushing severe chapped lips stomach pain headache dizziness loss of coordination Anyone who has taken an overdose of isotretinoin should know about the risk of birth defects caused by isotretinoin and should not donate blood for 1 month after the overdose. After an overdose, women who are capable of getting pregnant should use two types of birth control for a month.


However, you shouldn't dispose of this medication in the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. All medications should be kept out of the sight and reach of children, as many of the containers (such as weekly pill containers and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for small children to open. Keep this medication in the container it came in, tightly closed, and out of reach of children. If you do not have access to a take-back program, visit the FDA's Safe Disposal of Medicines website at for more details. Keep it at room temperature and out of the bathroom and other places with excessive heat and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them. Always lock safety caps and place the medication in a safe location - one that is up and away and out of their sight and reach.

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Side effects

Call your physician for advice on possible side effects. Typical negative effects may include: If you experience symptoms of an allergic reaction (hives, difficulty breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning eyes, skin pain, red or purple skin rash with blistering and peeling), seek emergency medical attention. Isotretinoin side effects (more detail) If you have: Stop using isotretinoin and contact your doctor right away. This is not a complete list of side effects and others may occur. Call 1-800-FDA-1088 to contact FDA and report side effects. Dryness of your skin, lips, eyes, or nose (you may experience nosebleeds); vision issues; headache, back pain, joint pain, muscle problems; skin reactions; or cold symptoms like a stuffy nose, sneezing, or sore throat. problems with your vision or hearing; muscle or joint pain, bone pain, back pain; increased thirst, increased urination; hallucinations, (see or hearing things that are not real); symptoms of depression--unusual mood changes, crying spells, feelings of low self-worth, loss of interest in things you once enjoyed, new sleep problems, thoughts about hurting yourself; signs of liver or pancreas problems--loss of appetite, upper stomach pain (that may spread to your back), nausea or vomiting, fast heart rate, dark urine, jaundice (yellowing of the skin or eyes); severe stomach problems--severe stomach or chest pain, pain when swallowing, heartburn, diarrhea, rectal bleeding, bloody or tarry stools; or increased pressure inside the skull--severe headaches, ringing in your ears, dizziness, nausea, vision problems, pain behind your eyes.


Dilantin (phenytoin), corticosteroids like fludrocortisone (Florinef), hydrocortisone, or dexamethasone. Take new medications only after consulting your doctor. Tell your doctor right away if you take vitamin A supplements. There may be interactions between isotretinoin and other medications, which could lead to serious side effects occasionally. The wort of John To show your doctor and pharmacist, keep a list of them. Know the medicines you take. St. Tetracycline antibiotics like doxycycline, tetracycline, or minocycline (Minocin) and progestin-only birth control pills (mini-pills) like Camilla and Norethindrone may increase the risk of side effects when taken together. Inform your doctor about every medication you take, including vitamins, herbal supplements, prescription drugs, and over-the-counter medications. Unless your doctor has given the all-clear, you should avoid taking these medications together with isotretinoin. Many of the side effects of isotretinoin are also present in high doses of vitamin A.


If you experienced any of these side effects while taking isotretinoin, you might also require post-treatment mental health care. Additionally, a few people have committed suicide. Isotretinoin is only prescribed to patients who are able to comprehend and consent to follow all of the guidelines in the iPLEDGE program because it has the potential to cause birth defects. Diabetes and other blood sugar issues are potential side effects of isotretinoin. Isotretinoin may have an adverse effect on your bones, muscles, and ligaments, which may result in joint or muscle pain. Reduced red and white blood cells: If you experience difficulty breathing, fainting, or feel weak, contact your doctor right away. If you are allergic to any of the ingredients in isotretinoin, do not take it. If you're pregnant, trying to get pregnant, or already have children, you shouldn't take isotretinoin. 2) Serious mental health issues. Doctors and patients should report all cases of pregnancy to the FDA MedWatch hotline at 1-800-FDA-1088 and the iPLEDGE pregnancy registry at 1-866-495-0654. Female patients must refrain from becoming pregnant for the following durations: one month prior to beginning isotretinoin, while taking isotretinoin, and one month after stopping isotretinoin. If you become pregnant while taking isotretinoin, stop taking it immediately and contact your doctor. Isotretinoin cannot be taken by female patients who are pregnant or who intend to become pregnant. Issues with your hearing: If your hearing deteriorates or you experience ringing in your ears, stop using isotretinoin and contact your doctor. Wearing contact lenses while taking isotretinoin and after treatment may be difficult for you if you wear them. If your organs are damaged, they may not get better even after you stop taking isotretinoin. In some patients a rash can be serious. 1) Birth defects (deformed babies), prenatal loss (miscarriage), infant death, and early (premature) births are serious side effects of isotretinoin. Birth defects from isotretinoin are very serious. Serious mental health issues may be brought on by isotretinoin. Suicide, psychosis (the perception of unreal sights or sounds), and depression are all potential side effects of isotretinoin. In teenagers who are still developing, isotretinoin may stop the growth of long bones. Problems with lipids (blood lipids and cholesterol): Isotretinoin can increase lipid (blood lipid) levels. A sign of serious muscle damage can be muscle weakness, whether or not it is accompanied by pain. There may be additional severe eye problems. To check your lipids and receive any necessary treatment, visit your doctor again. Blood tests will be performed. Serious allergic reactions: If you experience hives, a swollen face or mouth, or have trouble breathing, stop taking isotretinoin and seek emergency medical attention right away. Some isotretinoin patients have experienced suicidal thoughts, which are thoughts about harming oneself or ending one's own life. Some individuals have attempted suicide. Abdominal (stomach) issues: Some symptoms could indicate damage to your internal organs. If you experience muscle weakness, stop taking isotretinoin and call your doctor right away. Stop isotretinoin and call your doctor right away if you or a family member notices that you have any of the following signs and symptoms of depression or psychosis: start to feel sad or have crying spells lose interest in activities you once enjoyed sleep too much or have trouble sleeping become more irritable, angry, or aggressive than usual (for example, temper outbursts, thoughts of violence) have a change in your appetite or body weight have trouble concentrating withdraw from your friends or family feel like you have no energy have feelings of worthlessness or guilt start having thoughts about hurting yourself or taking your own life (suicidal thoughts) start acting on dangerous impulses start seeing or hearing things that are not real Other serious side effects: Serious brain problems: Isotretinoin can increase the pressure in your brain. Stop taking isotretinoin and call your doctor if you get a fever, rash or red patches or bruises on your legs. Stop taking isotretinoin and call your doctor if you get: severe stomach, chest or bowel pain. trouble swallowing or painful swallowing. new or worsening heartburn. diarrhea. rectal bleeding. yellowing of your skin or eyes. dark urine. If you experience any of these symptoms of elevated brain pressure, stop taking isotretinoin and contact your doctor right away: severe headache, blurred vision, dizziness, nausea, or vomiting, seizures (convulsions), stroke. Skin issues: Patients taking isotretinoin may experience skin rash. If you experience any vision issues or painful or persistent dry eyes, stop taking isotretinoin and contact your doctor right away. If you experience conjunctivitis (red or inflamed eyes, like "pink eye"), a rash with a fever, blisters on your legs, arms, or face, and/or sores in your mouth, throat, nose, or eyes, or if your skin starts to peel, stop using isotretinoin and contact your doctor right away. If you break a bone, let all your medical professionals know that you take isotretinoin. If you urinate a lot or are extremely thirsty, let your doctor know. Back pain, joint pain, or a broken bone should all be reported to your doctor. During isotretinoin treatment, let your doctor know if you intend to engage in any strenuous physical activity. These organs include the bowel (intestines), liver, pancreas, and esophagus (the tube connecting the mouth and stomach). When isotretinoin therapy is completed, these issues typically disappear. A serious issue could arise from this. This may result in permanent vision loss and, in extreme circumstances, death. When you stop taking isotretinoin, this condition usually gets better, but it might stay that way. Vision issues: Isotretinoin may make it difficult for you to see in the dark. Your hearing loss may be permanent.

What does isotretinoin do to your body?

Isotretinoin works by decreasing the size of the sebaceous glands in the skin. The sebaceous glands are responsible for creating sebum, the oil in skin that can clog pores and cause acne. When the sebum is controlled, breakouts stop.

Does isotretinoin permanently cure acne?

She recommended a six-month course of a powerful prescription pill called isotretinoin, better known by the now-defunct brand name Accutane. A single course typically lasts four to five months and often offers a prolonged cure for people who take it, according to the AAD. For some patients, this cure is permanent.

How long does Absorica take to work?

Absorica starts to work within 4 weeks but may take up to 20 weeks (5 months) for the full effects to be seen. Within four weeks of taking Absorica, a more than 33% reduction in the overall number of acne lesions was reported. Over 70% of people with severe nodular acne achieved a 90% reduction in the number of their nodular acne lesions after 20 weeks with Absorica. A single course of Absorica for 20 weeks has been shown to result in complete and prolonged remission of acne in many patients.

Does isotretinoin work permanently?

Most dermatologists agree that Isotretinoin is one of the few medications that can give prolonged control of acne even after the treatment course for many years, and in some instances, it is a permanent cure.

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Younes May 1, 2018, 4:39:11 PM

Do not donate blood till 30 days have passed after last capsule is taken. Isotroin Capsules During Breastfeeding It is not known whether isotretinoin passes into breast milk. There are no known drug-drug interactions between isotretinoin and ibuprofen/ creatinine/ vitamins other than Vitamin A/ Tylenol (paracetamol).

WarrenH Mar 17, 2012, 7:09:23 PM

In order to achieve the maximum possible efficacy in these patients the dose should normally be continued at the highest tolerated dose. Isotretinoin therapy should be started at a dose of 0.5 mg/kg daily. Isotretinoin should not be used for the treatment of prepubertal acne and is not recommended in children less than 12 years of age due to a lack of data on efficacy and safety. It has been shown that no substantial additional benefit is to be expected beyond a cumulative treatment dose of 120-150 mg/kg.

sivakumar KS Jun 7, 2017, 5:02:27 AM

Because severe cystic acne has the potential to cause permanent scarring over a short period, restrictions on its more immediate availability have proved contentious. In March 2018, European Medicines Agency issued a warning on a possible risk of neuropsychiatric disorders (such as depression, anxiety and mood changes) following the use of oral retinoids, including isotretinoin, though the limitations of the available data did not allow them to clearly establish whether this risk was due to the use of retinoids. In February 2002, Roche's patents for isotretinoin expired, and there are now many other companies selling cheaper generic versions of the drug. In 1985 the label was updated to include a boxed warning.

SadeepDarshana Oct 9, 2020, 12:38:47 AM

Acnex -20 is a retinoid, prescribed for acne and other skin disorders. Our Pharma Division deals only with the best, GMP certified generics and branded medication for the export market. • Please note for the minimum order for Exports is of US$ 100.

Eric Kok Sep 8, 2014, 10:15:41 AM

Since this drug can be absorbed through the skin and lungs and may harm an unborn baby, women who are pregnant or who may become pregnant should not handle this medication or breathe the dust from the capsules. The dosage is based on your medical condition, weight, and response to treatment. Take this drug with a full glass of water, and do not lie down for at least 10 minutes after taking it. Food helps increase absorption of this drug into your bloodstream.

Pellini Sep 6, 2019, 4:41:31 AM

Despite documented teratogenic effects, unplanned pregnancies do occur in females using agents classified as pregnancy category X or D. A ban on these drugs would have been the simplest solution to avoid embryopathy, but it would be a grave injustice to male patients and female patients of non-reproductive age group when an effective alternative does not exist. The need for medications that have unique effectiveness but with known teratogenicity and an obligation to prevent pregnancies exposed to such medications have led to the establishment of various pregnancy prevention programs (PPPs). The Food and Drug Administration (FDA) Amendment Act of 2007 enabled the United States FDA (US FDA) in cooperation with drug manufacturers to require a Risk Evaluation and Mitigation Strategies (REMS) for a biologic or a drug to ensure that its benefit outweighs the risk.

Abudi Khalil Oct 10, 2016, 10:35:48 PM

The capsule may take a few weeks to show some results, so do not stop taking the medicine early even if you do not notice any effect. Side effects of Isotretinoin Capsules It is rare for the medicine to show any side effects, in case you feel any symptom arising, get in touch with your doctor. Some common side effects of the capsules are: Dry skin Rashes Swelling of eyelids and lips Nose bleeding About the company Hacks and Slacks Healthcare is a highly reputed pharma company that is engaged in the production of quality skincare products. It may be prescribed alone or in combination with other drugs. It also acts as an anti-inflammatory, reducing skin inflammation.

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