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Amitriptyline is a member of the tricyclic antidepressant drug class. Depression symptoms can be treated with amitriptyline. It functions by raising the concentrations of some naturally occurring chemicals in the brain that are essential for maintaining mental equilibrium.

Other names for this medication:
Elavil

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Description

Amitriptyline may inhibit the membrane pump mechanism that is in charge of re-absorbing transmitter amines like norepinephrine and serotonin, increasing their concentration at synaptic clefts in the brain. This drug's mechanism of action is not fully understood. The monoamine hypothesis in depression, one of the oldest hypotheses, postulates that deficiencies of serotonin (5-HT) and/or norepinephrine (NE) neurotransmission in the brain lead to depressive effects. These amines play a critical role in mood regulation. This medication blocks these mechanisms, which may be how amitriptyline works to alleviate depressive symptoms. It is unknown whether its analgesic effects are connected to its mood-altering activities or due to a different, less obvious pharmacological action (or a combination of both).

Dosage

According to the clinical response, dose adjustments should be made. -Elderly patients should be closely watched and have clinically necessary serum levels taken. Once a satisfactory level of improvement has been reached, maintenance doses should be lowered to the lowest level necessary to maintain symptom relief. -To reduce the risk of relapse, maintenance therapy should be continued for three months or longer. The full therapeutic effect could take up to 30 days to manifest. 10 mg orally 3 times a day AND 20 mg orally once a day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. 12 years and older: 10 mg orally three times per day AND 20 mg orally once per day at bedtime Comments: -The full therapeutic effect may take as long as 30 days to develop. Comprehensive information on Amitriptyline dosage Maximum dose: 150 mg/day. Alternative outpatient treatment regimen: 50 to 100 mg orally as a single dose at bedtime. Initial dose: 100 mg orally per day. Maintenance dose: 40 to 100 mg orally as a single dose at bedtime. Use: Relieves depression-related symptoms Usual Adult Dose for Depression: Standard Geriatric Dose for Depression Usual Pediatric Dose for Depression

Missed dose

Never take two doses at once to make up for missed ones. To continue with your regular dosing schedule, skip the missed dose if it is almost time for the next one. When you remember, immediately take the missed dose.

Overdose

Amitriptyline abuse can have fatal consequences. Overdose symptoms may include irregular heart rhythm, feeling like you might pass out, seizures, or coma. Call the Poison Help hotline at 1-800-222-1222 or go to the emergency room.

Storage

You shouldn't flush this medication down the toilet, though. The best way to get rid of your medication is instead through a medication take-back program. As many containers (such as weekly pill minders and those for eye drops, creams, patches, and inhalers) are not child-resistant and are simple for young children to open, it is crucial to keep all medications out of sight and out of reach of children. Keep this medication tightly closed in its original container away from the reach of children. If you are unable to participate in a take-back program, visit the FDA's Safe Disposal of Medicines website at http://goo.gl/c4Rm4p for more details. It should not be kept in the bathroom. Store it at room temperature, away from sources of extreme heat and moisture. To find out about take-back programs in your area, speak with your pharmacist or the garbage/recycling department in your city. Always lock safety caps and put medication in a secure spot right away that is up and out of the way and out of reach of young children to prevent poisoning. http://www.upandaway.org To make sure that pets, kids, and other people cannot consume leftover medications, they should be disposed of in a specific manner.

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Side effects

To learn more, consult your physician or pharmacist. Call your physician for advice on possible side effects. This is not an exhaustive list of amitriptyline side effects, but some of the more common ones include: weakness, nausea, vomiting, drowsiness, headaches, blurred vision, changes in appetite and weight, problems urinating, pain or tingling in the hands or feet, changes in sex behavior, excessive sweating, confusion, and tachycardia (rapid heartbeat). See the "Drug Precautions" section. Amitriptyline has been associated with serious side effects. Call the FDA at 1-800-FDA-1088 to report side effects.

Interactions

Drug interactions with amitriptyline (more information) Before combining amitriptyline with a sleeping aid, narcotic pain reliever, muscle relaxant, or medication for anxiety, depression, or seizures, consult your doctor. The list of potential drug interactions is not exhaustive. Prescription, over-the-counter, vitamin, and herbal medications, as well as amitriptyline itself, may interact with other medications. Other medications you take may have their blood levels affected by certain medications, which could increase their side effects or reduce their efficacy. Utilizing a few medications at once is occasionally not advised. This effect may be exacerbated if you combine amitriptyline with other sedative medications. In particular, mention the following to your doctor: This is not an exhaustive list. Other antidepressants, drugs for colds or allergies (including Benadryl and similar products), drugs for Parkinson's disease, drugs for stomach issues, motion sickness, or irritable bowel syndrome, drugs for an overactive bladder, and bronchodilator asthma drugs are examples of medications that may be used to treat these conditions.

Contraindications

Mention any of the following: antihistamines, cimetidine (Tagamet), diet pills, disulfiram (Antabuse), guanethidine (Ismelin), ipratropium (Atrovent), quinidine (Quinidex), drugs for irregular heartbeats like flecainide (Tambocor) and propafenone (Rythmol), drugs for anxiety, asthma, colds, irritable bowel syndrome, Tell your doctor and pharmacist before taking amitriptyline if you are allergic to it or any other medications, and inform them if you are taking any monoamine oxidase (MAO) inhibitors, such as isocarboxazid (Marplan), phenelzine (Nardil), selegiline (Eldepryl, Emsam, Zelapar), or tranylcypromine (Parnate), or have taken one within the previous 14 days. If you are 65 years of age or older, talk to your doctor about the advantages and disadvantages of taking this medication. Do not breast-feed while using amitriptyline. Remember that alcohol can increase the drowsiness brought on by this medication, so do not drive a car or operate machinery until you know how it affects you. Call your physician right away if you get pregnant while taking amitriptyline. Amitriptyline is typically not recommended for older adults because it is not as safe or effective as other medication(s) that can be used to treat the same condition. If you are having surgery, including dental surgery, inform the doctor or dentist that you are taking amitriptyline. If you have stopped taking fluoxetine (Prozac, Sarafem) within the previous five weeks, tell your doctor right away. Your doctor may need to adjust your medication dosage or closely monitor you for side effects. Also, let them know if you've recently suffered a heart attack. Inform your doctor if you consume large amounts of alcohol, have or have ever had glaucoma (an eye condition), an enlarged prostate (a male reproductive gland), difficulty urinating, seizures, an overactive thyroid gland (hyperthyroidism), diabetes, schizophrenia (a mental illness that causes disturbed or unusual thinking, loss of interest in life, and strong or inappropriate emotions), liver, kidney, or any other organ disease. Inform your doctor and pharmacist about all of the prescription and nonprescription drugs, vitamins, dietary supplements, and herbal products you are taking. Your doctor will likely advise you not to take amitriptyline.

What will happen when I stop taking it?

If you've been feeling better for 6 months or more, your doctor may suggest coming off amitriptyline. Your doctor may recommend reducing your dose gradually over several weeks, or longer if you have been taking amitriptyline for a long time. This is to help prevent any withdrawal side effects you might get as a reaction to coming off the medicine. These include: feeling dizzy feeling sick numbness or tingling in the hands or feet trouble sleeping feeling agitated or anxious headaches shaking Important Do not stop taking amitriptyline suddenly, or without talking to your doctor first.

How will amitriptyline make me feel?

Many people sleep better while they're taking amitriptyline. Although amitriptyline is an antidepressant, the doses are lower to help pain. Taking amitriptyline as a painkiller will not change your personality or make you feel any different.

Is amitriptyline the most effective antidepressant?

The most effective antidepressant compared to placebo was the tricyclic antidepressant amitriptyline, which increased the chances of treatment response more than two-fold (odds ratio [OR] 2.13, 95% credible interval [CrI] 1.89 to 2.41).

Can you take amitriptyline for IBS?

Tricyclic agents such as amitriptyline and imipramine were initially prescribed to IBS patients with significant depression. Today, they are frequently used to treat patients with severe or refractory IBS symptoms and may have analgesic and neuromodulatory benefits in addition to their psychotropic effects.

Are there other treatments that will help?

Antidepressants, including amitriptyline, are just one of several approaches to treating depression. Other potential treatments include: talking therapy (such as cognitive behavioural therapy (CBT)) exercise programmes help to get a good night's sleep Choosing a treatment that's most suitable for you depends on: how long you've had depression your symptoms whether you've had depression before whether previous treatment has worked how likely you are to stick with your treatment the potential side effects your preferences and priorities

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yuloa Jul 14, 2021, 1:36:01 AM

Short-term studies did not show an increase in the risk of suicidality with antidepressants compared to placebo in adults beyond age 24; there was a reduction in risk with antidepressants compared to placebo in adults aged 65 and older. Antidepressants increased the risk compared to placebo of suicidal thinking and behavior (suicidality) in children, adolescents and young adults in short-term studies of major depressive disorder (MDD) and other psychiatric disorders. Follow patients for signs and symptoms of respiratory depression and sedation.

Jacob Daneman Jul 30, 2017, 10:04:19 PM

On the other hand, a patient who took a larger dose of this drug has to wait a longer period for its enzymes to work on the elimination and is at risk of overdose. Co-administered medications with this drug may either make the elimination faster or slower. To understand more about these factors, take a good read about the information below: CYP2D6 / CYP2C19 Metabolism In the body, there are enzymes called cytochrome P450 (CYP450), and these enzymes determine the elimination speed of Elavil.

dancek Jun 6, 2020, 9:01:41 PM

The mechanism of action of amitriptyline can harm women who are pregnant. Hence, it is not a good practice to take this drug while you are nursing a baby. It is very important to tell your treating doctor about nursing your baby prior to starting medication plans involving the intake of amitriptyline. Within its short half-life period, it controls the pumping mechanism of amines responsible for intra-membranous transmission of chemicals.

Dell Fuller Oct 16, 2010, 8:55:23 PM

Prophylactic treatment of chronic tension type headache and prophylactic treatment of migraine in adults Treatment must be continued for an appropriate length of time. The dose may be increased depending on individual patient response and tolerability. Elderly patients over 65 years of age and patients with cardiovascular disease A starting dose of 10 mg - 25 mg in the evening is recommended. The antidepressant effect usually sets in after 2 - 4 weeks. Recommended doses are 25 mg - 75 mg daily in the evening.

bdeo Jul 4, 2017, 10:49:03 PM

Amitriptyline 12.5mg + Chlordiazepoxide 5mg Tablet We Tanishq Life Care an Ahmedabad, Gujarat, India based Leading pharma company since 1999 offering Amitriptyline 12.5mg + Chlordiazepoxide 5mg under the brand name of LIBERA TAB. INDICATIONS Chlordiazepoxide/amitriptyline is used to treat people who have both depression and anxiety. It is also exported to South East and African countries.

Denbie Jul 21, 2015, 7:41:48 AM

However, using 10-30 mg of amitriptyline at night for headache doesn’t usually cause weight gain and the side effects are more tolerable. They make a 100 mg tab of amitriptyline, but I never use it. My personal medical experience is that amitriptyline is also a useful drug for nocturnal, middle of the night, and early morning “wake up” headaches. Aimovig, one of the new CGRP drugs for migraine, costs $540 per month without insurance.

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